Claudiu Supuran
|
Name |
Claudiu Supuran |
|
|
supuran@ksu.edu.sa |
|
Address |
Department of Chemistry, College of Science, Building (5) Office: 2A146 Telephone: 4675992 |
|
Project Title |
Dendrimers conjugated with carbonic anhydrase inhibitors and activators functionalities |
|
Project Summary |
Various dendrimers (low and high molecular weight) will be derivatized with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors and activators functionalities. The CA inhibitors will include sulfonamides, sulfamates, sulfamides, coumarins and dithiocarbamates/xanthates. The CA activators will include amines, amino acids and oligopeptides. These dendrimers will be tested for their activity on a large number of mammalian (human), bacterial, fungal and archaeal CAs, and the active ones may be tsted for in vivo action as antiglaucoma and antitumor agents/diagnostic tools. |
